论文部分内容阅读
目的观察不同剂量5-氟脲嘧啶(5-Fu)腹腔化疗对胃肠肿瘤术后免疫系统的影响。方法检测7例胃癌与33例大肠癌根治术后6个疗程腹腔化疗前后的体液免疫与细胞免疫指标的变化。结果在每一疗程化疗前后的短期内免疫系统均未受抑制;随着5-Fu剂量在各疗程的逐步递增,血IgG、IgA、C_4、CD_3及NK活性明显下降低于对照组。结论 5-Fu腹腔化疗能抑制机体的体液免疫与细胞免疫。
Objective To observe the effects of different doses of 5-fluorouracil (5-Fu) intraperitoneal chemotherapy on postoperative immune system of gastrointestinal cancer. Methods The changes of humoral immunity and cellular immunity before and after intraperitoneal chemotherapy in 7 cases of gastric cancer and 33 cases of colorectal cancer were detected. Results The immune system was not inhibited for a short period of time before and after each course of chemotherapy. As the dose of 5-Fu gradually increased during each course of treatment, the levels of IgG, IgA, C4, CD3, and NK were significantly lower than those of the control group. Conclusion 5-Fu intraperitoneal chemotherapy can inhibit the body’s humoral and cellular immunity.