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我们对34例急性白血病(AL)合并中枢神经系统白血病(CNS-L)和82例AL不合并CNS-L患者进行了脑脊液(CSF)中β2-微球蛋白(β2-MG)、铁蛋白(Ft)和癌胚抗原(CEA)含量测定。结果表明:合并CNS-L患者CSF中的各单项标记物平均含量均高于不合并CNS-L患者。用阶梯分割线法分析β2-MG+CEA或≥β2-MG+Ft联合应用的结果表明双标记物联合测定的诊断特异性、敏感性和准确性均优于单一标记物。
We performed a retrospective study of 34 patients with acute leukemia (AL) complicated with central nervous system leukemia (CNS-L) and 82 patients with AL without CNS-L who underwent cerebrovascular (CSF) β2-microglobulin Ft) and carcinoembryonic antigen (CEA) content. The results showed that the average content of each single marker in the CSF of patients with CNS-L was higher than those without CNS-L. The results of the combined use of β2-MG + CEA or ≥β2-MG + Ft by ladder-line analysis showed that the diagnostic, specificity and accuracy of the dual-label combination assay were superior to single label.