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我们对３４例急性白血病（ＡＬ）合并中枢神经系统白血病（ＣＮＳ－Ｌ）和８２例ＡＬ不合并ＣＮＳ－Ｌ患者进行了脑脊液（ＣＳＦ）中β２－微球蛋白（β２－ＭＧ）、铁蛋白（Ｆｔ）和癌胚抗原（ＣＥＡ）含量测定。结果表明：合并ＣＮＳ－Ｌ患者ＣＳＦ中的各单项标记物平均含量均高于不合并ＣＮＳ－Ｌ患者。用阶梯分割线法分析β２－ＭＧ＋ＣＥＡ或≥β２－ＭＧ＋Ｆｔ联合应用的结果表明双标记物联合测定的诊断特异性、敏感性和准确性均优于单一标记物。
We performed a retrospective study of 34 patients with acute leukemia (AL) complicated with central nervous system leukemia (CNS-L) and 82 patients with AL without CNS-L who underwent cerebrovascular (CSF) β2-microglobulin Ft) and carcinoembryonic antigen (CEA) content. The results showed that the average content of each single marker in the CSF of patients with CNS-L was higher than those without CNS-L. The results of the combined use of β2-MG + CEA or ≥β2-MG + Ft by ladder-line analysis showed that the diagnostic, specificity and accuracy of the dual-label combination assay were superior to single label.