用复脉汤对大白鼠进行为期３个月（第１批）及３５个月（第２批）的毒性试验，着重对实验大鼠的心、肝、肾、脑等１１个重要脏器进行组织形态学及组织化学观察。结果表明各组实验动物上述脏器的组织学变化均相似，都属正常的组织结构；心、肝组织中琥珀酸脱氢酶（ＳＤＨ）和乳酸脱氢酶（ＬＤＨ）等均呈强阳性反应，上述结果提示复脉汤是安全可靠的方剂，从而为该方剂适于临床长期应用提供了形态学的实验依据 The rats were treated with Fumai Tang for 3 months (1st batch) and 3-5 months (2nd batch) toxicity tests, focusing on 11 important organs such as heart, liver, kidney, and brain of experimental rats. The organizer performs histological and histochemical observations. The results showed that the histological changes of the above-mentioned organs were similar in all experimental groups, and they were all normal tissue structures; SDH and LDH were strongly positive in heart and liver tissues. The above results suggest that Fumai Decoction is a safe and reliable prescription, providing experimental basis for the prescription to be suitable for clinical long-term application.