自Abrikossoff1926年报告肌母细胞瘤以来,已普遍认为颗粒细胞瘤是一个肯定的病变.这种病变可见于许多不同器官,如舌、皮肤、软组织、乳腺和消化器官。多发性颗粒细胞瘤及恶变型也有报告。关于它的组织发生已提出许多理论。已报导横纹肌细胞、吞噬细胞、雪旺氏细胞、神经内和周围神经纤维母细胞为病损的起始部位。某些作者提出多细胞来源超过单细胞来源。另一些作者提出,此病起源于未分化的间叶细胞。神经源性理论最为广泛接受。近来,一些免疫组织化学研究指出,神经系统特异性蛋白(S—100)定位于颗粒细胞中。通过在颗粒细胞中检 Since Abrikossoff’s 1926 report of myoblastoma, it has been widely accepted that granulosa cell tumors are a sure lesion. This lesion can be found in many different organs, such as the tongue, skin, soft tissue, breast and digestive organs. Multiple granulosa cell tumors and malignant transformation have also been reported. Many theories have been put forward about its occurrence. It has been reported that striated muscle cells, phagocytic cells, Schwann cells, intraneural and peripheral nerve fibroblasts are the starting sites of lesions. Some authors propose that multicellular sources outnumber single cell sources. Other authors suggest that the disease originates from undifferentiated mesenchymal cells. Neurogenic theory is the most widely accepted. Recently, some immunohistochemical studies have indicated that nervous system-specific proteins (S-100) are localized in granule cells. By examining in granule cells