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本文报告钙通道阻滞剂硝苯啶合并β阻滞剂普萘洛尔治疗原发性高血压38例6mo。疗效观察:硝苯啶口服起效时间15-30min,高峰时间1-1.5h,和普萘洛尔联用服6mo后,药效可维持36-48h,72h仍能低于基础血压。平均降压5.6/2.6kPa(42.1/19.4mmHg),总有效率达97％。经随机分组30例作同期对照,结果表明,两药并用,剂量小,副作用少,效果显著。是一组简便、速效、安全的药物组合,用于重症高血压应急处理和慢性高血压维持治疗。
This article reports the calcium channel blockers nifedipine combined with beta blockers propranolol in the treatment of 38 cases of essential hypertension in 6 months. Efficacy of the observation: nifedipine oral onset time 15-30min, peak time 1-1.5h, and propranolol combined service 6mo, the efficacy can be maintained for 36-48h, 72h still lower than the basic blood pressure. The average step-down 5.6 / 2.6kPa (42.1 / 19.4mmHg), the total effective rate of 97%. A randomized group of 30 cases for the same period control, the results show that the two drugs used in combination with small doses, fewer side effects, the effect is significant. Is a combination of simple, quick, safe combination of drugs for emergency treatment of severe hypertension and chronic hypertension maintenance treatment.