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将１例人肺高分化腺癌手术标本直接移植于ＮＩＨ裸小鼠皮下，建立了ＣＥＡ高表达人肺高分化腺癌裸小鼠移植瘤模型（ＬＡＸ─９１），裸鼠间已传３２代，历时２年余。ＬＡＸ─９１潜伏期短，生长稳定，移植成功率１００％。各代移植瘤病理组织学观察均保持了原病人肿瘤的结构，并且有分泌功能，染色体分析显示人恶性肿瘤特征。血清ＣＥＡ含量多次测定结果表明，ＬＡＸ─９１具有稳定高分泌ＣＥＡ的生物学特性。该移植瘤模型的建立，为进一步研究人肺癌和癌胚抗原的关系提供了有用的手段。
One case of human lung adenocarcinoma was transplanted subcutaneously into NIH nude mice. A nude mouse model of human lung adenocarcinoma with high expression of CEA was established (LAX ─ 91) , Lasted more than 2 years. LAX ─ 91 incubation period is short, stable growth, transplant success rate of 100%. Histopathological examination of the xenografts of all generations maintained the structure of the original patient’s tumor and had secretory function. Chromosome analysis showed the characteristics of human malignant tumors. The results of serum CEA assay for many times showed that LAX ─ 91 has the biological characteristics of stable and high secretion of CEA. The establishment of the xenograft model provides a useful method for further studying the relationship between human lung cancer and carcinoembryonic antigen.