目的:探讨急性前循环大血管闭塞性脑卒中血管内治疗联合高压氧干预的有效性与安全性。方法:选取联勤保障部队第九〇二医院150例急性前循环大血管闭塞性脑卒中患者，随机分为血管内治疗组和联合治疗组(血管内治疗＋高压氧治疗)，所有患者均采用血管内治疗，术后采用改良脑梗死溶栓血流分级(mTICI)评价血管再通，记录术后出血转化、血管再闭塞并发症发生率，采用美国国立卫生研究院卒中量表(NIHSS)评价入院时、术后24 h及高压氧治疗1个疗程后神经功能，通过观察患者血同型半胱氨酸(HCY)及超敏C-反应蛋白(hs-CRP)治疗前后水平变化及随访90 d采用改良Rankin量表(mRS)评价预后。同期选择75例未采取血管内治疗的急性前循环大血管闭塞性脑卒中患者作为对照组。结果:150例患者中血管再通血流分级达mTICI≥2b级为126例，mTICI<2b级为24例。术后并发血管再闭塞3例，症状性颅内血肿6例。术后24 h NIHSS评分显著低于入院时，且高压氧治疗后NIHSS评分进一步改善。术后90 d mRS评分预后良好者98例，不良者52例。血HCY及hs-CRP较治疗前显著下降。结论:急性前循环大血管闭塞性脑卒中采用血管内治疗是安全、有效的，术后联合高压氧治疗可以显著改善患者预后及生活质量。“,”Objective:To explore efficacy and safety of endovascular therapy combined with hyperbaric oxygen (HBO) intervention in acute anterior circulation macrovascular occlusion stroke.Methods:A total of 150 patients with acute anterior circulation macrovascular occlusive stroke admitted in No.902 Hospital of the CPLA Joint Logistic Support Force were selected and randomly divided into endovascular treatment group and combined treatment group (endovascular+ HBO). Endovascular therapy was adopted in the treatment of all patients. Modified thrombolytic flow grading (mTICI) was used to evaluate vascular recanalization after operation, and the incidences of complications of hemorrhage transformation and vascular re-occlusion were recorded. National institutes of health stroke scale (NIHSS) was used to evaluate the neurological functions on admission, at 24 hours after the operation, and one course after HBO therapy. The prognosis was evaluated by observing the changes of blood homocysteine (HCY) and high-sensitivity C-reactive protein (hs-CRP) levels before and after treatment. The patients had been followed up by the modified Rankin Scale (mRS) for 90 days. At the same time, 75 patients with acute anterior circulation macrovascular occlusive stroke without taking endovascular treatment were selected as the control group.Results:Among 150 patients, 126 cases had a grade of mTICI≥2b, while 24 cases had a grade of mTICI<2b. Postoperative vascular re-occlusion occurred in 3 cases, and symptomatic intracranial hematoma occurred in 6 cases. The NIHSS score at 24 hours after the operation was significantly lower than that on admission, and the NIHSS score was further improved after HBO treatment. Ninety days after the operation, mRS showed 98 cases of good prognoses, while 52 cases of poor prognoses. The levels of HCY and hs-CRP were significantly lower than those before the treatment.Conclusion:Endovascular therapy for acute anterior circulation macrovascular occlusive stroke is safe and effective. Postoperative HBO therapy can significantly improve the prognosis and the quality of life of patients.