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为优化青蒿琥酯现场应用预防血吸虫感染方案 ,选择铜陵市灰河乡太阳村江滩型血吸虫病重流行区 ,根据人群接触疫水特点 ,将人群分为短期接触疫水人群 (年接触疫水时间 <1个月 ) ,中期接触疫水人群 (年接触疫水时间为 2～ 3个月 )和长期接触疫水人群 (年接触疫水时间为整个感染季节 ) ,分别施以不同服药方案。3类人群按随机原则分别分为青蒿琥酯组和安慰剂对照组。预防服药前 1个月对所有观察对象进行粪检及吡喹酮 (PQT) 4 0 m g/kg顿服普治 ,各组人群均于末次服药后 1个月作粪检 ,评价预防效果。结果显示 ,短期、中期和长期接触疫水人群中 ,口服青蒿琥酯组粪检阳性率分别为 0 (0 /2 10 )、0 (0 /311)和 0 .48% (1/2 0 9) ;对照组粪检阳性率分别为 6 .2 5 % (13/2 0 8)、5 .45 % (17/312 )和 8.7% (18/2 0 7) ,3类人群的预防保护率分别为 10 0 %、10 0 %和 94.48%。研究表明 ,在江滩型血吸虫病流行区根据人群接触疫水特点而实施不同服药方案可起到较好的预防血吸虫感染的效果 ,且可避免药物的浪费 ,有利于该药的现场推广应用
In order to optimize the application of artesunate in the prevention and treatment of schistosomiasis, we selected the severe epidemic area of schistosomiasis in Taiyangcun, Taihe, Tonghe City. According to the characteristics of population exposure to polluted water, the population was divided into short- Water time <1 month), medium-term exposure to water-exposed people (contact with water for 2 to 3 months) and long-term exposure to water (contact with water for the entire infectious season), were given different medication programs . Three groups were randomly divided into artesunate group and placebo control group. One month before taking the medication, all the subjects were tested for stool and puerarin (PQT) 40 mg daily for the first time. All groups were tested for prophylaxis one month after the last dose. The results showed that the positive rates of stool test in oral artesunate group were 0 (0/2 10), 0 (0/311) and 0 .48% (1/2 0) in short-, medium- and long- 9). The positive rates of fecal examination in the control group were 6.5% (13/2 0 8), 5.45% (17/312) and 8.7% (18/2 0 7) Rates were 100%, 100% and 94.48% respectively. Studies have shown that in the endemic areas of schistosomiasis endemic to rivers, different medication regimens can be used to prevent schistosomiasis infection according to the characteristics of population exposure to water and avoid the waste of drugs, which is beneficial to the promotion and application of this medicine in the field