CD44属于粘附分子家族的Ⅰ型跨膜糖蛋白,是一种骨髓细胞外基质糖胺聚糖-透明质酸(HA)的主要受体。CD44最初叫淋巴细胞归巢受体,因与淋巴细胞归巢有关而得名。最近发现CD44不仅限于淋巴细胞,它广泛存在于大多数脊椎动物的细胞表面,介导细胞与细胞或细胞与细胞外基质之间粘附作用 CD44 is a type I transmembrane glycoprotein of the adhesion molecule family and is a major receptor for myeloid extracellular matrix glycosaminoglycans, hyaluronic acid (HA). CD44 was originally called lymphocyte homing receptor, named for its association with lymphocyte homing. It has recently been found that CD44 is not limited to lymphocytes and is present extensively on the cell surface of most vertebrates and mediates adhesion between cells and cells or cells and the extracellular matrix