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目的 探讨变应性鼻炎患者的T淋巴细胞亚群改变。方法 应用间接免疫荧光法对 6 9例变应性鼻炎进行T淋巴细胞亚群测定。结果 常年性变应性鼻炎及季节性变应性鼻炎的发作期CD8+ 明显低于对照组 (P <0 .0 1) ,而CD3 + 、CD4 + 及CD4/CD8均显著高于对照组 (P <0 .0 1)。结论 T淋巴细胞介导的细胞免疫功能异常在变应性鼻炎的发病及发展中起重要作用
Objective To investigate the changes of T lymphocyte subsets in patients with allergic rhinitis. Methods Indirect immunofluorescence assay was used to detect T lymphocyte subsets in 69 patients with allergic rhinitis. Results The percentage of CD8 + in patients with perennial allergic rhinitis and seasonal allergic rhinitis was significantly lower than that in the control group (P <0.01), but CD3 +, CD4 + and CD4 / CD8 were significantly higher than those in the control group (P <0 .0 1). Conclusion T lymphocyte-mediated cellular immune dysfunction plays an important role in the pathogenesis and development of allergic rhinitis