论文部分内容阅读
目的探讨血管紧张素转换酶(ACE)与糖尿病并脑血管疾病患者血压的关系。方法选取2014—2015年宝鸡市人民医院收治的糖尿病并脑血管疾病患者124例,根据血压分为高血压组54例和非高血压组70例。比较两组患者一般资料和实验室检查指标。结果两组患者性别、年龄、糖尿病病程、脑血管疾病病程、BMI、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)比较,差异无统计学意义(P>0.05);高血压组患者血清ACE水平高于非高血压组(P<0.05)。Pearson相关分析结果显示,血清ACE水平与糖尿病并脑血管疾病患者收缩压、舒张压均呈正相关(P<0.05)。多因素logstic回归分析结果显示,血清ACE水平是糖尿病并脑血管疾病患者发生高血压的危险因素(P<0.05)。结论血清ACE水平与糖尿病并脑血管疾病患者血压呈正相关,是糖尿病并脑血管疾病患者发生高血压的危险因素
Objective To investigate the relationship between angiotensin converting enzyme (ACE) and blood pressure in patients with diabetes mellitus and cerebrovascular diseases. Methods A total of 124 patients with diabetes mellitus and cerebrovascular disease were enrolled in Baoji People’s Hospital from 2014 to 2015. They were divided into hypertension group (n = 54) and non-hypertension group (n = 70) according to blood pressure. The two groups of patients were compared with the general information and laboratory test indicators. Results The gender, age, duration of diabetes, duration of cerebrovascular disease, BMI, fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL- There was no significant difference in HDL-C (P> 0.05). The level of serum ACE in hypertensive patients was higher than that in non-hypertensive patients (P <0.05). Pearson correlation analysis showed that there was a positive correlation between serum ACE levels and systolic and diastolic blood pressure in patients with diabetes mellitus and cerebrovascular disease (P <0.05). Multivariate logistic regression analysis showed that serum ACE level was a risk factor for hypertension in patients with diabetes mellitus and cerebrovascular disease (P <0.05). Conclusion Serum ACE level is positively correlated with blood pressure in patients with diabetes mellitus and cerebrovascular disease and is a risk factor for hypertension in patients with diabetes mellitus and cerebrovascular disease