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我们应用免疫组织化学方法 ,检测43例骨肉瘤和 15例骨软骨瘤手术标本中细胞周期素Ｄ1(ｃｙｃｌｉｎＤ1)、ｐ16、Ｒｂ蛋白的表达 ,探讨 3种基因表达在骨肉瘤发生发展中的意义 ,现报道如下。一、材料和方法1.标本 :中国医科大学附属第一、二医院骨科 1986～ 1998年手术切除骨肉瘤
We used immunohistochemical methods to detect the expression of cyclin D1, p16, and Rb proteins in surgical specimens of 43 cases of osteosarcoma and 15 cases of osteochondroma, and to explore the significance of the expression of these three genes in the development of osteosarcoma. The report is as follows. I. Materials and Methods 1. Specimens: Orthopaedic Surgery of the First and Second Hospital Affiliated to China Medical University 1986 to 1998 Surgical resection of osteosarcoma