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目的探讨血小板源性生长因子(PDGF-BB)在阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)合并高血压患者中的变化及在OSAHS相关高血压发病过程中可能的作用机制。方法测定30例健康对照者、43例单纯OSAHS患者、51例OSAHS合并高血压患者及27例中重度OSAH合并高血压患者nCPAP治疗后血清PDGF-BB水平。结果单纯OSAHS组,OSAHS合并高血压组血清PDGF-BB水平均较正常对照组升高(P<0.05);OSAHS合并高血压组血清PDGF-BB水平较单纯OSAHS组升高(P<0.05),较对照组仍有差异。结论单纯OSAHS患者可能出现血管功能和结构的改变,参与OSAHS相关高血压的病理过程。
Objective To investigate the changes of platelet-derived growth factor (PDGF-BB) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with hypertension and its possible role in the pathogenesis of OSAHS-related hypertension mechanism. Methods Serum levels of PDGF-BB were measured in 30 healthy controls, 43 patients with OSAHS alone, 51 OSAHS patients with hypertension and 27 patients with moderate-to-severe OSAH complicated with hypertension. Results The levels of PDGF-BB in OSAHS group and OSAHS group were significantly higher than those in OSAHS group (P <0.05). The levels of PDGF-BB in OSAHS group were higher than those in OSAHS group (P <0.05) Still different than the control group. Conclusions The OSAHS patients may have changes in vascular function and structure, and participate in the pathological process of OSAHS-related hypertension.