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目的研究ｎｍ２３－Ｈ１，ＰＣＮＡ在肺癌中的表达与肺癌转移的关系。方法应用免疫组化ＳＰ法检测４７例肺癌中ｎｍ２３－Ｈ１，ＰＣＮＡ的表达。结果原发性肺癌中ｎｍ２３－Ｈ１，ＰＣＮＡ的阳性率分别为５１．０６％和６５．９６％。其中ｎｍ２３－Ｈ１在鳞癌中的阳性率４３．３３％（１３／３０），腺癌６４．７０％（１１／１７）。在鳞癌中无肺门及纵膈淋巴结转移阳性率６２．５％（１０／１６），有转移组阳性率２１．４２％（３／１４），差异有显著性（Ｐ＜０．００１），ｎｍ２３－Ｈ１表达与鳞癌的淋巴结转移呈负相关。在ＰＣＮＡ表达中有淋巴结转移阳性率８２．６％（１９／２３），无转移组５４．１６％（１３／２４）（Ｐ＜０．００１），同时低分化癌的阳性率８８．８８％（８／９）明显高于高分化癌４３．７５％（７／１６），（Ｐ＜０．００１）。结论ｎｍ２３－Ｈ１，ＰＣＮＡ的表达对肺癌予后评估有一定意义。
Objective To investigate the relationship between the expression of nm23-H1 and PCNA in lung cancer and the metastasis of lung cancer. Methods Immunohistochemical SP method was used to detect the expression of nm23-H1 and PCNA in 47 cases of lung cancer. Results The positive rates of nm23-H1 and PCNA in primary lung cancer were 51.06% and 65.96%, respectively. Among them, the positive rate of nm23-H1 in squamous cell carcinoma was 43.33% (13/30) and adenocarcinoma was 64.70% (11/17). The positive rate of hilar and mediastinal lymph node metastasis was 62.5% (10/16) in squamous cell carcinoma and 21.42% (3/14) in metastasis group, with a significant difference (P<0.001). , nm23-H1 expression was negatively correlated with lymph node metastasis in squamous cell carcinoma. The positive rate of lymph node metastasis was 82.6% (19/23) in the expression of PCNA, 54.16% (13/24) in the non-metastatic group (P<0.001), and the positive rate of poorly differentiated carcinoma was 88.88%. (8/9) was significantly higher than that of well-differentiated carcinoma 43.75% (7/16) (P<0.001). Conclusion The expression of nm23-H1 and PCNA has a certain significance for post-assessment of lung cancer.