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对于祖孙、叔侄、同胞、半同胞等隔代基因遗传的亲缘关系鉴定,可采用ITO法计算似然率值LR进行判断[1]。然而在某些特定的案例中,采用ITO法,即使大量增加STR基因座检测数,也不能有效提高LR值,可采用家系基因型重建法[2-3],以便获得确定亲缘关系的支持证据。本文通过1例半同胞鉴定案例,介绍该分析方法为同行参考。1案例鉴定1.1简要案情本实验室受理1例因遗产纠纷需进行半同胞亲
For the grandchildren, nephews, nephews, siblings, half siblings and other offspring genetic genetic relationship identification, ITO method can be used to calculate the likelihood ratio LR to judge [1]. However, in some specific cases, using the ITO method, even if the number of STR loci detected is increased significantly, the LR value can not be effectively increased. Therefore, the pedigree genotyping method [2-3] can be used in order to obtain supporting evidence for the determination of kinship . In this paper, a case of half sibling identification case, introduced the analysis method for peer reference. 1 Case Identification 1.1 Brief Case The laboratory accepts 1 case due to the legacy of disputes need to be half-siblings