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目的：观察性研究临床上治疗消化性溃疡时联合抗抑郁药的疗效。方法：选择本院自2013年1月-2013年6月收治的55例患有消化性溃疡而住院者的临床资料，随机分组，将患者分为试验组28例与对照组27例，对照组消化性溃疡患者采用单纯的溃疡治疗的用药方式，试验组患者在治疗溃疡用药的基础上联合抗抑郁药[1]，观察并比较两组患者的用药后的临床疗效。结果：两组患者经治疗后比较其临床疗效，试验组临床疗效高于对照组比较显著，两组治疗结果相比较，结果出现显著性差异（P＜0．05），即两组具有可比性。结论：采用常规溃疡治疗药物联合抗抑郁治疗药物的方法在治疗消化性溃疡具有比较好的临床效果。“,”Objective To observe the clinical treatment of peptic ulcer studies w hen combined antidepressant effect .Methods hospital from January 2013 -2013 in June were treated 55 cases of hospitalized persons suffering from peptic ulcer clinical data randomization ,patients were divided into test group of 28 patients and the control group of 27 patients in the control group to digest ulcers in patients using a simple ulcer treatment is administered ,the test ulcer medication in the treatment of patients on the basis of joint antidepressants [1 ] , the two groups were observed and compared the clinical efficacy after treatment .Results After treatment ,the two groups were compared the clinical efficacy ,clinical efficacy trial group was significantly higher compared two groups compared treatment outcomes ,resulting in a significant difference (P <0 .05) ,the two groups were comparable .Conclusion ulcer therapy combined with conventional antidepressant therapy ap-proach in the treatment of peptic ulcer with good clinical results .