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Moricizine已在苏联、美国等地广泛使用或研究。作者采用电生理测试、经食道左房调搏、动态心电图监测和运动试验等方法,研究Moricizine的效用。一、临床电生理 1.Moricizine对窦房结功能的电生理效应 Ruffy等将1×10~(-6)～1×10~(-4)g/ml浓度的Moricizine注入窦房结动脉,窦性周期长度(SCL)未显著延长,故认为Moricizine对窦房结自律性无明显影响。作者采用静脉注入Moricizine 1.5～2.0mg/kg的方法。窦房结功能正常者SCL缩短(27例,799±120～777±110ms,p<0.001),纠正的窦房结恢复时间(CSRT)缩短(27例,296±89～270±71ms,p<0.05),而窦房传导时间(SACT)延长(12例,166±33
Moricizine has been widely used or studied in the Soviet Union, the United States and other places. The author uses electrophysiological tests, transesophageal and atrial tachycardia, Holter monitoring and exercise tests and other methods to study the utility of Moricizine. First, the clinical electrophysiology 1.Moricizine electrophysiological effect on sinus node function Ruffy and other will be 1 × 10 ~ (-6) ~ 1 × 10 ~ (-4) g / ml concentration of Moricizine into the sinus node, sinus Sexual cycle length (SCL) was not significantly prolonged, so that Moricizine sinus node self-regulation had no significant effect. The authors used intravenous Moricizine 1.5 ~ 2.0mg / kg method. The sinoatrial node function was normal in patients with SCL shortening (27 cases, 799 ± 120 ~ 777 ± 110ms, p <0.001), corrected sinus node recovery time (CSRT) shortened (27 cases, 296 ± 89 ~ 270 ± 71ms, p < 0.05), while sinoatrial conduction time (SACT) was prolonged (12 patients, 166 ± 33