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目的:研究细胞周期素依赖性激酶抑制蛋白27(p27kip1)和细胞S相激酶相关蛋白2(skp2)在肺癌癌组织中的表达及意义。方法:选取于我院就诊的72例肺癌患者的肺癌组织和20例癌旁正常肺组织,采用免疫组化技术检测标本中p27kip1和skp2的表达,并分析其与患者的临床病理之间的关系。结果:skp2在肺癌组织中的表达高于正常肺组织,而p27kip1在肺癌组织中的表达低于正常肺组织,差异均有统计学意义(P<0.05),且两者的表达呈负相关关系,相关系数r=-0.855(P<0.05),skp2的表达与肺癌组织学类型、分化程度、TNM分期、淋巴结有无转移、吸烟与否及p27kip1蛋白表达有关(P<0.05)。结论:p27kip1低表达和skp2高表达可能是肺癌发生发展的重要原因,可应用于临床诊治肺癌患者和判断预后。
Objective: To investigate the expression and significance of cyclin-dependent kinase-inhibiting protein 27 (p27kip1) and S-phase kinase-related protein 2 (skp2) in lung cancer. Methods: Totally 72 lung cancer patients and 20 normal lung tissues adjacent to our hospital were selected for immunohistochemical detection of p27kip1 and skp2, and their relationship with clinical pathology was analyzed . Results: The expression of skp2 in lung cancer tissues was higher than that in normal lung tissues, while the expression of p27kip1 in lung cancer tissues was lower than that in normal lung tissues (P <0.05), and the expression of skp2 was negatively correlated , The correlation coefficient r = -0.855 (P <0.05). The expression of skp2 was correlated with the histological type, differentiation degree, TNM stage, lymph node metastasis, smoking or not and the expression of p27kip1 protein (P <0.05). Conclusion: The low expression of p27kip1 and high expression of skp2 may be the important reasons for the development of lung cancer. It may be used in clinical diagnosis and treatment of patients with lung cancer and prognosis.