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内源性吗啡样多肽(简称内啡肽)是近年来从脑、垂体、肠分离出来的一类具有吗啡样活性的神经多肽,目前已达8种,它们可能是一类新的神经递质或神经调节物质。其中脑啡肽是两个5肽:亮-脑啡肽及甲硫-脑啡肽,其脑内分布与(阿片)受体有相当显著的平行关系。β-内啡肽首先发现于垂体,然后亦在脑内找到。在脑内给药时其镇痛作用比脑啡肽强而持久。最近有许多资料提示脑刺激或针剌引起的镇痛都可能是由于激活了脑内的内啡肽能神经原使之释放内啡肽。本文讨论了有关的进展。
Endogenous morphine-like peptide (endorphin) is a kind of morphine-like activity peptide isolated from brain, pituitary and intestine in recent years. Up to now, there are 8 kinds of neuropeptides, which may be a new type of neurotransmitter Or neuromodulatory substances. Among them, enkephalin is the two 5-peptide: enkephalin and methione-enkephalin, and the distribution in the brain has quite significant parallel relationship with (opioid) receptors. Beta-endorphin is first found in the pituitary gland and then in the brain. Its analgesic effect is stronger and longer lasting than enkephalins when administered intracerebrally. Recently there are many data suggest that brain stimulation or acupuncture induced analgesia may be due to the activation of endorphin neurons in the brain so that the release of endorphins. This article discusses the progress.