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目的探讨降钙素原(PCT)在新生儿重症感染时的诊断价值。方法将自2002年3～12月于天津市儿童医院新生儿科住院的229例新生儿分别归入无感染对照组(116例),全身感染组(39例),局部感染组(51例)和病毒感染组(23例)。检测入院时血清PCT和C反应蛋白(CRP),白细胞计数及分类。用SPSS10.0ForWindows进行数据分析。结果在全身感染时,血清PCT和CRP质量浓度升高均有显著性,但PCT显著性更高(P<0.001)。PCT≥2μg/L作为全身感染的诊断依据,其敏感度(0.804)和特异度(0.824)均优于CRP。结论与CRP和白细胞计数相比,PCT是一个较好的新生儿全身细菌感染的诊断指标。
Objective To investigate the diagnostic value of procalcitonin (PCT) in severe neonatal infections. Methods A total of 229 newborns hospitalized in neonatal department of Tianjin Children’s Hospital from March to December in 2002 were enrolled in the control group (116 cases), systemic infection group (39 cases), local infection group (51 cases) and Virus infection group (23 cases). Serum PCT and C-reactive protein (CRP), white blood cell count and classification were detected at admission. SPSS10.0ForWindows for data analysis. Results In systemic infection, the serum PCT and CRP concentrations were significantly elevated, but PCT was significantly higher (P <0.001). PCT ≥ 2μg / L as the basis for the diagnosis of systemic infection, the sensitivity (0.804) and specificity (0.824) were better than CRP. Conclusion Compared with CRP and leukocyte count, PCT is a good diagnostic indicator of systemic bacterial infection in neonates.