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调查了混苯接触及健康对照人群１１７名，应用外周血淋巴细胞８－羟基－２－脱氧鸟苷（８－ＯＨｄＧ），微核（ＭＮ）作为苯遗传毒性指标，尿粘康酸（ＴＴＭＡ）作为苯内接触标记物，观察甲苯对苯代谢及遗传毒性的抑制作用。结果表明甲苯可抑制原ＴＴＭＡ的排出，还可抑制外周血淋巴细胞８－ＯＨｄＧ，ＭＮ的形成，未发现甲苯有诱导职业接触人群外周血淋巴细胞８－ＯＨｄＧ，ＭＮ形成及白细胞（ＷＢＣ）下降的作用。
A total of 117 mixed benzene exposure and healthy control subjects were investigated. Peripheral blood lymphocyte 8-hydroxy-2-deoxyguanosine (8-OHdG) and micronuclei (MN) As a benzene in-vivo contact marker, observe the inhibition of benzene on benzene metabolism and genotoxicity. Toluene could inhibit the excretion of TTMA and inhibit the formation of 8-OHdG and MN in peripheral blood lymphocytes. Toluene-induced peripheral blood lymphocyte 8-OHdG, MN formation and WBC decreased effect.