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脑微血管病变(MVA)与临床上多种血管危险因素有关,具有组织学特征,包括动脉血管壁增厚,Virchow-Robin间隙(VRS)的扩大。我们曾描述了MVA基于MRI的2种新的生物学标志,即VRS间隙的扩大以及因脑血管壁顺应性下降导致的动脉收缩期搏动异常传导至脑室内脑脊液。这些与血管性痴呆及难治性迟发性抑郁症(treatment-resistant lateonset depression)有关。
Cerebral microangiopathy (MVA) is associated with a number of clinically significant vascular risk factors and has histological features including thickening of the arterial wall and enlargement of the Virchow-Robin space (VRS). We described two new biomarkers of MVA based on MRI: the expansion of the VRS gap and the conduction of systolic beats due to decreased compliance of the cerebral vascular wall to the cerebroventricular cerebrospinal fluid. These are related to vascular dementia and treatment-resistant lateonset depression.