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用酶联免疫吸附测定法测定７５例原发性肝癌、１４０例乙型肝炎肝硬化和５３例慢性乙型肝炎的乙型肝炎病毒５项标志．结果，原发性肝癌组以乙型肝炎表面抗原、乙型肝炎核心抗体和乙型肝炎ｅ抗体同时阳性最多见，占３６％（２７／７５），其次为乙型肝炎表面抗原和乙型肝炎核心抗体同时阳性，为２７％（２０／７５）；在乙型肝炎肝硬化组以乙型肝炎表面抗原和乙型肝炎核心抗体同时阳性最为多见，为２９％（４１／１４０），其次为乙型肝炎表面抗原、乙型肝炎核心抗体同时阳性，为２８％（３９／１４０），但这两种模式在两组之间相比差异无显著．而乙型肝炎表面抗原、乙型肝炎ｅ抗原和乙型肝炎核心抗体同时阳性在原发性肝癌组为７％（５／７５），与慢性乙型肝炎（４７％）组相比差异显著；与乙型肝炎肝硬化组（２３％）相比差异显著；乙型肝炎肝硬化组与慢性乙型肝炎组相比差异显著．肝癌组乙型肝炎表面抗原、乙型肝炎核心抗体阳性率相对较低，而乙型肝炎ｅ抗体相对较高．由此可见，长期乙型肝炎表面抗原、乙型肝炎核心抗体和乙型肝炎ｅ抗体同时阳性与肝硬化、肝癌密切相关，而乙型肝炎ｅ抗体长期存在与肝癌的发病率有明显关系．
The enzyme-linked immunosorbent assay was used to determine five markers of hepatitis B virus in 75 cases of primary liver cancer, 140 cases of hepatitis B cirrhosis and 53 cases of chronic hepatitis B. Results: Hepatitis B surface antigen, hepatitis B core antibody, and hepatitis B e antibody were most common in the primary liver cancer group, accounting for 36% (27/75), followed by hepatitis B surface antigen and hepatitis B. The core antibody was positive at the same time, being 27% (20/75); the hepatitis B surface antigen and hepatitis B core antibody were most common in the hepatitis B cirrhosis group, with 29% (41/140), followed by Hepatitis B surface antigen and hepatitis B core antibody were positive at the same time (28% (39/140)), but there was no significant difference between the two groups in the two groups. The positive levels of hepatitis B surface antigen, hepatitis B e antigen, and hepatitis B core antibody in the primary liver cancer group were 7% (5/75), and they were significantly different from those in the chronic hepatitis B group (47%). Compared with the hepatitis B cirrhosis group (23%), the difference was significant; the difference between the hepatitis B cirrhosis group and the chronic hepatitis B group was significant. In the liver cancer group, the positive rate of hepatitis B surface antigen and hepatitis B core antibody was relatively low, while the hepatitis B e antibody was relatively high. This shows that long-term hepatitis B surface antigen, hepatitis B core antibody and hepatitis B e antibody are both positively related to cirrhosis and liver cancer, and long-term presence of hepatitis B e-antibodies has a significant relationship with the incidence of liver cancer.