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本文对276例HBsAg阳性母亲及其新生儿血清进行HBV标志检测。母血HBeAg和PHSA-R阳性率分别为48.9％和52.9％。婴儿脐血HBsAg阳性率9.8％(27/276)。对276例新生儿按0、1、3、6月程序,每次肌肉注射乙肝疫苗10μg进行阻断研究。生后9月龄,脐血HBsAg阴性组212例抗-HBs阳转率86.8％,随访24月龄时抗-HBs阳性率91.4％。脐血HBsAg阳性组27例抗HBs阳转率51.9％,9例HBsAg持续阳性。母血HBV标志和婴儿性别对疫苗阻断效果无明显影响。抗-HBs阳转组婴儿血清PHSA-R和HBV-DNA检测均阴性。表明单独使用乙肝疫苗阻断乙肝病毒母婴传播可取得满意效果。
In this paper, HBV markers were detected in 276 HBsAg positive mothers and their newborns. The positive rates of HBeAg and PHSA-R in maternal blood were 48.9% and 52.9% respectively. The positive rate of HBsAg in infant cord blood was 9.8% (27/276). A total of 276 neonates were challenged with 0, 1, 3, and 6 months of intramuscular injection of 10 μg of hepatitis B vaccine. The positive rate of anti-HBs in 212 HBsAg-positive patients with cord blood HBsAg positive rate was 86.8% at 9 months after birth. The positive rate of anti-HBs was 91.4% at 24 months of follow-up. 27 cases of cord blood HBsAg positive group anti-HBs positive rate of 51.9%, 9 cases of HBsAg continued positive. Maternal blood HBV markers and infant sex had no significant effect on vaccine blockade. Anti-HBs positive group of infant serum PHSA-R and HBV-DNA test were negative. The results showed that using hepatitis B vaccine alone could block the mother-to-child transmission of hepatitis B virus and achieve satisfactory results.