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目的探讨还原型谷胱甘肽和维生素E对酒精性肝病(ALD)的保护作用。方法 64例ALD患者随机分为实验组和对照组,每组32例。实验组服用还原型谷胱甘肽(阿拓莫兰片)和维生素E胶囊,对照组不服药。比较恢复饮酒6个月后两组患者丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、AST/ALT、γ-谷氨酰转肽酶(GGT)、红细胞平均体积(MCV)及脂肪肝严重程度变化的差异。结果实验后两组患者ALT、AST、AST/ALT、GGT、MCV均出现不同程度升高,但对照组升高更为明显,组间各指标比较差异具有统计学意义(P<0.05);实验后实验组和对照组的中度脂肪肝的检出率分别为25.0%(8/32)和50.0%(16/32),组间比较差异具有统计学意义(P<0.05)。结论还原型谷胱甘肽和维生素E对继续饮酒的ALD患者肝脏有部分保护作用。
Objective To investigate the protective effects of reduced glutathione and vitamin E on alcoholic liver disease (ALD). Methods 64 patients with ALD were randomly divided into experimental group and control group, 32 cases in each group. Experimental group taking reduced glutathione (ATOMO Lan tablets) and vitamin E capsules, the control group did not take medicine. The levels of ALT, AST, AST / ALT, γ-glutamyl transpeptidase (GGT), the average volume of erythrocytes (MCV) and the average volume of erythrocytes Differences in the severity of fatty liver changes. Results The levels of ALT, AST, AST / ALT, GGT and MCV in the two groups increased to some extent after the experiment, but the levels in the control group were more obvious. The differences among the groups were statistically significant (P <0.05) The detection rates of moderate fatty liver in experimental group and control group were 25.0% (8/32) and 50.0% (16/32), respectively. The difference between the two groups was statistically significant (P <0.05). Conclusion Reduced glutathione and vitamin E have partial protective effect on the liver of ALD patients who continue to drink alcohol.