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抗原呈递过程中 ,细胞之间的信号交换是启动和维持免疫反应的关键。Ｔ细胞的完全活化除需ＣＤ3 ＴＣＲ/ＭＨＣ Ａｇ提供的抗原特异性信号外 ,还需共刺激分子提供辅助信号即共刺激信号。目前主要共刺激通路是Ｂ7家族成员和ＣＤ4 0 ＣＤ15 4受体 配体体系。ＩＣＯＳ(ｉｎｄｕｃ
During antigen presentation, the exchange of signals between cells is the key to initiating and maintaining an immune response. In addition to the antigen-specific signal provided by CD3 TCR / MHC Ag, complete activation of T cells requires co-stimulatory molecules to provide helper or costimulatory signals. Currently the main costimulatory pathway is a member of the B7 family and the CD4 0 CD15 4 receptor ligand system. ICOS (induc