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目的:了解不同剂量米非司酮治疗未破裂型异位妊娠的临床效果。方法:对我院2011年12月至2013年12月收治的未破裂型异位妊娠患者进行抽样,选取120例患者随机分成三组,每组40例,其中A组予以米非司酮总剂量为1050mg,,B予以米非司酮总剂量达3150mg,C组予以总剂量达6900mg,均为2周疗法,观察三组患者临床疗效。结果:C组腹痛消失时间、血β-HCG恢复正常时间、阴道流血时间、盆腔包块消失时间明显低于A、B组(P<0.05),且不良反应发生率明显高于A、B组(P<0.05)。结论:大剂量米非司酮治疗未破裂型异位妊娠疗效颇佳,但易出现恶心呕吐、便秘、皮疹、水肿等不良反应。
Objective: To understand the clinical efficacy of different doses of mifepristone in the treatment of unruptured ectopic pregnancy. Methods: A total of 120 patients with unruptured ectopic pregnancy who were admitted to our hospital from December 2011 to December 2013 were selected and randomly divided into three groups (40 cases in each group). The total dose of mifepristone in group A 1050mg ,, B to mifepristone a total dose of 3150mg, C group to a total dose of 6900mg, were 2 weeks therapy, the clinical efficacy of the three groups were observed. Results: The disappearance time of abdominal pain, the normal time of recovery of blood β-HCG, the time of vaginal bleeding and the disappearance of pelvic masses in group C were significantly lower than those in groups A and B (P <0.05), and the incidence of adverse reactions was significantly higher than that in groups A and B (P <0.05). Conclusion: High dose of mifepristone is effective in the treatment of unruptured ectopic pregnancy, but prone to nausea and vomiting, constipation, rash, edema and other adverse reactions.