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[目的]探讨微创单髁置换术治疗膝关节内侧间室骨性关节炎的初步疗效与手术技术.[方法]回顾性分析2005年5月～2008年12月采用微创单髁置换术治疗45例(48膝)膝关节内侧问室骨性关节炎患者的资料,对患者术前、术后膝关节疼痛及关节活动度进行评估(HSS评分法),测量术后膝关节力线并与术前测量结果比较,分析手术适应证的选择及手术技术.[结果]40例(43膝)术后平均随访24个月(12～40个月),关节内侧间室疼痛症状明显减轻或消失,膝关节活动度达到平均120°(0°～135°),术后力线为平均内翻2°(0°～内翻6°),HSS评分由术前70分(60～82分)增至90分(75～95分),优良率达92%.[结论]微创单髁置换术治疗膝关节内侧间室骨性关节炎具有很好的疗效,其关键在于手术适应证的选择和手术技术.“,”[Objective]To explore the short-term outcome and surgical technique of minimally invasive unicondylar knee arthroplasty(MIS-UKA)for medial compartmental osteoarthritis of the knee.[Methods]Forty-five patients(48 knees)with medial compartmental osteoarthritis of knee treated by MIS-UKA from May 2005 to December 2008 were reviewed and analyzed.The pain and range of motion(ROM)of the knees were evaluated by HSS score system before and after MISUKA.Pre-and postoperative alignment of the lower limbs was measured and compared.Surgery indications and surgical technique of MIS-UKA were also summarized.[Results]Forty-three knees in 40 patients were followed up for a mean time of 24 months(12-40 months).The pain over medial compartment of the knees was subsided or relieved in all cases.The postoperative ROM of the knees was 0°～135°(mean 120°),and alignment was 2° varus on the average(0°～6° varus).HSS score increased from 70(60～82)to 90(75～95).The good-to-excellent rate was 92%.[Conclusion]MIS-UKA is an effective method for medial compartmental osteoarthritis of the knee.Surgery indications and surgical technique are the key factors for the final results.