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恶性疟原虫对药物产生抗性,阻碍着控制疟疾的进程。为制定合理的综合防治方案,我们选择了一个抗药性恶性疟暴发的小区,进行研究,并获得了迅速控制流行的满意效果,现报告如下。1 试区情况勐腊县加布托垦区,位于北纬21°31′以南,东经101°以东,约10km的河谷区。有2个居民点,人口259人,系疟疾病灶点。另有10个新建定居点。1990年8月入现场调查,9月份发病较高的7个定居点的月发病率高达17.6％(72/409),P.f.占43.1％(31/72),P.V.占56.9％(41/72)。现场用氯喹1.5g试治4例;复方乙胺嘧啶片(磺胺多辛250mg,乙胺嘧啶17.5mg/片)试治12例,证实该地区属抗氯喹、抗复方乙胺嘧啶恶性疟流行区。1990年体外测定抗体率100％(44/44),
Plasmodium falciparum resistance to drugs hinder the control of malaria. In order to formulate a reasonable comprehensive prevention and control program, we have chosen a community of drug-resistant falciparum malaria outbreaks for research and obtained the satisfactory results of rapid control of the epidemic. The report is as follows. 1 The situation of the test area Mengla County Gabatore reclamation area, located in latitude 21 ° 31 ’north, east longitude 101 °, about 10km of the valley area. There are 2 settlements, a population of 259 people, Department of malaria lesions. Another 10 new settlements. In a field survey conducted in August 1990, the monthly incidence rates of the seven settlements with high incidence in September were as high as 17.6% (72/409), Pf accounted for 43.1% (31/72) and PV accounted for 56.9% (41/72) . Four patients were treated with chloroquine 1.5g on the spot, and 12 were treated with pyrimethamine tablets (sulfadoxine 250mg and pyrimethamine 17.5mg / tablet), which confirmed that the patients were resistant to chloroquine and anti-pyrimethamine in the endemic area . 1990 in vitro determination of antibody rate of 100% (44/44),