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本文报告28例恶性组织细胞病,全部病例均经尸解证实。病变以浸润为主,常侵犯脾、肝、淋巴结、骨髓和胸腹等浆膜,累及肺、肾及心脏者也不少。临床上每例均有发热,除肝、脾、淋巴结肿大外,黄疸及肺部啰音也属常见。本病以累及多脏器为特点。病灶分布缺乏规律性。同一器官内恶组细胞浸润的程度也缺少均匀性,可散在浸润,也可聚集成粟粒样或肉芽肿样病灶。本病的诊断应该是综合性的:临床表现结合多部位骨髓穿刺和活检仍为主要诊断手段。应尽可能争取淋巴结活检。肝穿刺具有危险性而阳性率不高。浆膜腔积液的细胞学检查对确立本病的诊断有所帮助。
This article reports 28 cases of malignant cell disease, all confirmed by autopsy. Infiltration of lesions mainly invading the spleen, liver, lymph nodes, bone marrow and chest and abdomen and other serosa, lung, kidney and heart involvement are also many. Each case of clinical fever, in addition to liver, spleen, lymph nodes, jaundice and pulmonary rales are also common. The disease is characterized by involvement of multiple organs. Lack of regularity of the distribution of lesions. In the same organ, there is also a lack of homogeneity in the degree of malignant cell infiltration, which can diffuse into infiltration, but also gather into miliary-like or granulomatous-like lesions. The diagnosis of the disease should be comprehensive: the clinical manifestations combined with multi-site bone marrow biopsy and biopsy is still the main diagnostic tool. As far as possible for lymph node biopsy. Liver puncture is dangerous and the positive rate is not high. Cytofluid cytological examination to establish the diagnosis of the disease helpful.