目的：研制替硝唑凝胶。方法：用卡波姆９４０ 作凝胶基质制备替硝唑凝胶，建立了酸碱度、卫生学、含量测定等质量控制标准，对制剂进行了刺激性试验，离心试验，留样观察，光照试验。结果：ｐ Ｈ 值４ ．５ ～７ ．０ ，卫生学检查符合规定，含量测定平均回收率为１００ ．２６ ％ ， Ｒ Ｓ Ｄ 为０ ．８７ ％ （ ｎ ＝ ６） ，且凝胶稳定无变化，无刺激性。结论：本方法设计合理，稳定性好，可满足临床需要。 Objective: To develop tinidazole gel. Methods: The tinidazole gel was prepared by using carbomer  940 as gel matrix, and the quality control standards such as pH, hygiene and content determination were established. The irritation test, centrifuge test, sample observation, light test . Results: p H value 4. 5 ~ 7. 0, hygiene inspection in line with the provisions of the determination of the average recovery rate of 100. 26%, R S D is zero. 87% (n = 6), and no change in the stability of the gel, non-irritating. Conclusion: The method is reasonable in design and good in stability to meet clinical needs.