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目的 :探讨常压下不同低氧 ( 1 4 5 %、1 2 6%氧含量 )模拟高住低练对心肌血管内皮生长因子mRNA表达的影响 ,为运动与低氧适应提供理论依据。方法 :用RT -PCR技术检测大鼠心肌VEGFmRNA水平。结果 :常压下不同低氧模拟高住低练对大鼠心肌VEGFmRNA表达作用结果不同 ,常压下 1 4 5 %氧含量 (相当于海拔 3 0 0 0m)模拟高住低练能稳定VEGF的上调 ,而在常压下1 2 6%氧含量 (相当于海拔 40 0 0m)模拟高住低练时VEGFmRNA基因表达量却减少。结论 :只有选择在适宜的氧含量 (海拔高度 )进行高住和安排好运动训练持续时间 (低练 )才能有效地提高大鼠心肌VEGFmRNA的表达水平
OBJECTIVE: To investigate the effects of hypoxia (1 45%, 122% oxygen) simulating live-in training on the mRNA expression of myocardial vascular endothelial growth factor (HIF-1α) under normal pressure, and provide a theoretical basis for exercise and hypoxia adaptation. Methods: The level of VEGF mRNA in rat myocardium was detected by RT-PCR. Results: Under hypobaric hypobaric hypobaric hypoxia, the effects of high and low exercise on VEGF mRNA expression in rat myocardium were different. Under normal pressure, the content of 154% oxygen (equivalent to altitude of 3000m) , While the expression of VEGFmRNA decreased at 120% atmospheric pressure (equivalent to an altitude of 40 000 m). Conclusion: Only by choosing the right oxygen content (altitude) to live and arrange exercise duration (low training) can effectively improve the expression of VEGFmRNA in rat myocardium