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苯妥英是目前广泛使用的抗癫痫药物。茶碱同样是对哮喘患者经常使用的强心利尿药。实际在临床上这两种药物合并应用的较多。为此Miller博士对苯妥英与茶碱并用时对苯妥英改变茶碱的体内动态进行了试验。试验是在无吸烟习惯的6名健康者(男性4人女性2人)进行。首先每个受试者在15分钟内按每公斤体重给与5mg的氨茶碱静脉注射,单独给予茶碱时观察了体内动态。随后每天服用苯妥英300mg
Phenytoin is currently widely used antiepileptic drugs. Theophylline is also a cardiotonic diuretic commonly used in asthma patients. The actual application of these two drugs in clinical practice more. To this end, Dr. Miller tested phenytoin with theophylline in combination with phenytoin to change the in vivo dynamics of theophylline. The test was performed on 6 healthy people (4 males and 2 females) without a habit of smoking. First, each subject was given intravenous injections of 5 mg of aminophylline per kilogram of body weight over 15 minutes, and the in vivo dynamics were observed when theophylline was administered alone. Then take phenytoin 300mg daily