肺炎链球菌(Streptococcus pneumoniae,S.p)在世界范围内仍然是一种重要的病原体,可引起肺炎、脑膜炎、中耳炎、鼻窦炎及菌血症等多种严重疾病〔1-2〕。为了及时准确地检测出疑似病例是否为肺炎链球菌感染,需要有灵敏特异的检测方法。虽然从样本中分离到肺炎链球菌被公认为是金标准,但实际在肺炎链球菌性肺炎的成人病例中,能够分离到菌株的 Streptococcus pneumoniae (S.p.) is still an important pathogen in the world and can cause many serious diseases such as pneumonia, meningitis, otitis media, sinusitis and bacteremia [1-2]. In order to timely and accurately detect whether the suspected cases of Streptococcus pneumoniae infection, the need for sensitive and specific detection methods. Although S. pneumoniae isolated from samples is recognized as the gold standard, in fact, in an adult case of pneumococcal pneumonia, it is possible to isolate