论文部分内容阅读
目的：探讨鼻咽癌（NPC）组织PCNA的表达与其临床进展、病理组织分型的相互关系。方法：用免疫组化S－P法检测113例NPC和25例鼻咽慢性炎的PCNA表达。结果：103例NPC和3例鼻咽慢性炎呈PCNA阳性。NPC呈PCNA低增殖频率者，倾向于Ⅰ、Ⅱ期临床分期（87．1％）及无淋巴结转移（70．96％）。高增殖频率者，倾向于Ⅲ、Ⅳ期临床分期（82．1％）及有淋巴结转移（79．49％）。增殖频率与NPC临床分期及淋巴结转移有非常显著差异（P＜0．01）。结论：反映细胞增殖的PCNA增殖频率与临床分期、淋巴结转移密切相关，可作为NPC进展的重要参考指标。
Objective: To investigate the relationship between the expression of PCNA in nasopharyngeal carcinoma (NPC) and its clinical progression and histopathological classification. Methods: The expression of PCNA in 113 cases of NPC and 25 cases of chronic nasopharyngitis was detected by immunohistochemical S-P method. Results: 103 cases of NPC and 3 cases of nasopharyngeal chronic inflammation were PCNA positive. Patients with low proliferative frequency of PCNA tended to stage Ⅰ and Ⅱ clinical staging (87.1%) and no lymph node metastasis (70.96%). Those with high proliferative rate tended to stage Ⅲ and Ⅳ clinical stage (82.1%) and had lymph node metastasis (79.49%). Proliferation frequency and NPC clinical stage and lymph node metastasis are very significant difference (P <0.01). CONCLUSION: The frequency of proliferation of PCNA, which reflects cell proliferation, is closely related to clinical stage and lymph node metastasis and may be used as an important reference index for the progress of NPC.