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目的:研究分析外周血联合胸腔积液应用T SPOT-TB检测对于诊断结核性胸膜炎的临床效果。方法:选取60例胸腔积液患者,将其中的30例结核性胸膜炎病患设为结核组,剩余的30例非结核性胸膜炎病患设为非结核组,为两组均进行外周血联合胸腔积液应用T SPOT-TB检测,进行抗酸杆菌涂片检测、TST试验及用酶偶联测定法测定ADA活性。结果:外周血诊断结核性胸膜炎的敏感性和特异性分别25(83.33%)及27(90.12%);胸腹水诊断结核性胸膜炎的敏感性和特异性分别为26(86.67%)及29(96.57%);胸腔积液的斑点数显然比外周血要高。结论:外周血联合胸腔积液应用T SPOT-TB检测对于诊断结核性胸膜炎具有较好的效果,能够明显的避免及减少结核性胸膜炎的误诊率,提高结核性胸膜炎的临床确诊率。
Objective: To study the clinical effect of T-SPOT-TB in the diagnosis of tuberculous pleurisy in peripheral blood combined with pleural effusion. Methods: Thirty patients with tuberculous pleurisy were enrolled in this study. Thirty patients with tuberculous pleurisy were enrolled as the tuberculosis group. The remaining 30 patients with non-tuberculous pleurisy were enrolled in the non-tuberculosis group. The effusion was detected by T SPOT-TB, tested for acid-fast bacilli smear, TST test and enzyme-linked assay for ADA activity. Results: The sensitivity and specificity of peripheral blood in the diagnosis of tuberculous pleurisy were 25 (83.33%) and 27 (90.12%) respectively. The sensitivity and specificity of pleural and ascitic fluid in diagnosing tuberculous pleurisy were 26 (86.67%) and 29 %); Pleural effusion is obviously higher than the number of peripheral blood. Conclusion: The combination of peripheral blood and pleural effusion using T SPOT-TB test has a good effect on the diagnosis of tuberculous pleurisy. It can obviously avoid and reduce the misdiagnosis rate of tuberculous pleurisy and improve the clinical diagnosis rate of tuberculous pleurisy.