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本文采用放射性核素示综枝术研究了久效磷在小鼠体内含量分布与致死性效应的关系,相应观察了不同致死剂量久效磷对小鼠血和脑胆碱脂酶活性抑制程度的差异。实验表明:久效磷急性中毒致死与脑内毒物的含量有较密切的关系。同时发现LD_(50)剂量中毒存活的小鼠,血和脑内胆碱脂酶活性受抑制程度与同剂量及超致死剂量中毒死亡小鼠之间无显著性差异。本文对久效磷致死的毒理机制造行了初步探讨。
In this paper, the relationship between the content distribution of monocrotophos and the lethal effect of monocrotophos in mice was studied by means of radionuclide quantification, and the inhibitory effects of different lethal doses of monocrotophos on blood and brain cholinesterase activity in mice were observed. difference. Experiments show that the death caused by monocrotophos acute poisoning has a close relationship with the content of toxic substances in the brain. At the same time, there was no significant difference in the inhibition of blood and brain cholinesterase activity in mice that survived LD_(50) dose poisoning with those mice that died of the same dose and super dead dose poisoning. This paper discusses the manufacture of poisoning machine that kills monocrotophos.