基因治疗是近几年来生物学研究关注的焦点和热点,而癌症基因治疗一直是其应用的主要领域,飞速的发展使人们不断打破对基因治疗概念的传统理解,但基因治疗仍存在的问题是缺乏安全和高效的基因导入系统。现在大多采用的是腺病毒、腺相关病毒、逆转录病毒以及慢病毒等载体系统,但都有各自的局限性和特异性,随着分子生物学的进展,载体携带的外源基因种类、功能的多样化,新的治疗手段层出不穷。 Gene therapy is the focus and hotspot of biological research in recent years. Cancer gene therapy has been the main field of its application. The rapid development has led to the continuous breaking of the traditional understanding of the concept of gene therapy, but the problem of gene therapy is that Lack of safe and efficient gene delivery system. Nowadays most of them are adenovirus, adeno-associated virus, retrovirus and lentivirus vector system, but have their own limitations and specificities, with the progress of molecular biology, vector carrying foreign gene types, functions Diversification, new treatments emerge in an endless stream.