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本文综合上海地区部分医疗单位对慢性萎缩性胃炎(CAG)的一些研究资料,包括病因学调查,光学和电子显微镜的病理学观察,泌酸功能的研究,血清胃泌素的测定,以及免疫学方面的一些研究等。调查提示吸烟、饮食不规则、胆汁返流等因素可能和 CAG 的发生有关。指出壁细胞泌酸功能与胃窦的萎缩性变化及肠腺化生程度有关,而按胃酸分泌功能和试餐后血清胃泌素值变化来分型,更能准确反映胃窦和胃体的病理生理。以酶免疫法测定壁细胞抗体(PCA)的阳性率高于免疫荧光法.因 PCA 测定有假阳性,故认为其仅示有胃粘膜的损害,而对 CAG 的诊断并无特异性.本文提出,CAG 可分为 A、B_1和 B_2诸型,在我国华东地区以 B 型为多见.观察发现,我国的 A 型患者临床上很少出现恶性贫血.
This article summarizes some research data on chronic atrophic gastritis (CAG) in some medical institutions in Shanghai, including etiological investigations, pathological observations by optics and electron microscopy, studies on oxyntic function, determination of serum gastrin, and immunology. Some aspects of the study and so on. Investigations suggest that smoking, irregular diet, bile reflux and other factors may be related to the occurrence of CAG. It was pointed out that the oxyntic function of the parietal cells was related to the atrophic changes of gastric antrum and the degree of intestinal metaplasia, while typing according to the function of gastric acid secretion and changes in serum gastrin values after a meal was more accurate in reflecting the antrum and the gastric body. Pathophysiology. The positive rate of the parietal cell antibody (PCA) measured by enzyme immunoassay was higher than that of immunofluorescence assay. Because of the false positive test of PCA, it was considered that it only showed gastric mucosal damage, but the diagnosis of CAG was not specific. , CAG can be divided into A, B_1 and B_2 various types, in China’s East China region with B-type is more common. Observed that China’s A-type patients clinically rare pernicious anemia.