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目的 探讨米索前列醇 (米索 )用于中期引产时米索的最适剂量和给药途径。方法 将 91例 15～ 32wk要求终止妊娠的孕妇 ,分为A、B、C3组。 3组均于入院当天口服已烯雌酚 5mgtid× 1d ,A组于当晚 8时口服米非司酮 15 0mg、米索 2 0 0 μg、次晨 8时口服米索 2 0 0 μg、如宫缩不好 ,3～ 4h追加 1次。如晚 8时后产程无进展则不再给药 ,次晨 8时如前述追加米索至胎儿排出。B组仅次日将米索 2 0 0 μg改为阴道给药 ,余同A组。C组将米索减量到 15 0 μg ,余同B组。观察 3组引产时间、米索用量、产后出血、残留发生率及副反应。结果 3组引产时间、米索用量、产后出血、残留率间无显著性差异 ,P >0 0 5。平均引产时间约为 36h。 3组中C组的副反应趋于减少。结论 上述 3种药用于中期引产时 ,以米索 15 0 μg阴道用药更安全可靠。
Objective To investigate the optimal dosage and route of administration of misoprostol (misoprostol) for misoprostol during mid-term induction of labor. Methods Ninety-one pregnant women who required termination of pregnancy from 15 to 32 weeks were divided into A, B and C3 groups. 3 groups were on the day of oral administration of diethylstilbestrol 5mgtid × 1d, A group at 8 o’clock in the evening oral mifepristone 150mg, misoprostol 200μg, the next morning 8:00 oral misoprostol 200g, such as the palace Shrink is not good, 3 ~ 4h additional 1. Such as late at 8 o’clock no progress of labor is no longer dosing, 8 o’clock the morning after the additional misoprostol to the fetus. The second day of group B, misoprostol 200 μg was changed to vaginal administration, the same as in group A. Group C reduced the amount of misoprostol to 15 0 μg, the rest with the B group. Three groups were observed the induction of labor, the amount of misoprostol, postpartum hemorrhage, the incidence of residual and side effects. Results There were no significant differences between the three groups in induction of labor, consumption of misoprostol, postpartum hemorrhage and residual rate (P> 0.05). The average induction of labor is about 36h. Side effects of group C in group 3 tended to decrease. Conclusion The above three kinds of drugs for mid-term induction of labor, vaginal administration of misoprostol 150 g more secure and reliable.