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３５只大鼠随机分为四组，Ａ组为正常对照组，Ｂ组为谷氨酰胺肠外营养组（ＧＬＮ－ＴＰＮ），Ｃ组为不含ＧＬＮ的常规ＴＰＮ组和经肠道营养的Ｄ组。内毒素以２ｍｇ／ｋｇ／ｄ的剂量，混入营养液或生理盐水中，持续滴注５天。结果显示，Ｂ组肠壁蛋白质和ＤＮＡ含量高于Ｃ组，其中回肠蛋白质含量有显著差别（Ｐ＜０．０５）。在绒毛高度、小肠粘膜及全层厚度等指标Ｂ组也明显优于Ｃ组（Ｐ＜０．０５），经肠道营养的Ｄ组在上述组织学观察数值上均与正常相近，且粘膜厚度、绒毛高度均超过正常值（Ｐ＜０．０５）。Ｂ、Ｄ二组肠道内细菌移位率均低于Ｃ组（Ｐ＜０．０５）。研究结果提示，加入ＧＬＮ的ＴＰＮ有助于防止败血症大鼠肠萎缩及细菌移位。早期应用经肠道营养更具有积极的生理意义。
35 rats were randomly divided into four groups: group A was normal control group, group B was glutamine parenteral nutrition group (GLN-TPN), group C was conventional TPN group without GLN and group D group. Endotoxin 2mg / kg / d dose, mixed with nutrient solution or saline, continuous infusion for 5 days. The results showed that the content of protein and DNA in the intestinal wall of group B was higher than that of group C, and the content of ileal protein was significantly different (P <0.05). In group B, the indexes of villus height, small intestinal mucosa and full thickness were also significantly better than those in group C (P <0.05). The intestinal histological values in group D of intestinal nutrition were similar to those in normal group, and mucosal thickness , The height of the villus exceeded the normal value (P <0.05). The intestinal bacterial translocation rates in group B and group D were lower than those in group C (P <0.05). The results suggest that the addition of GLN TPN helps prevent intestinal atrophy and bacterial translocation in rats with sepsis. Early application of enteral nutrition more positive physiological significance.