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目的探讨手术联合术后放疗治疗涎腺腺泡细胞癌的临床效果。方法回顾性分析2003-2016年新疆医科大学第一附属医院颌面肿瘤外科收住的经手术及术后放疗治疗18涎腺腺泡细胞癌患者的临床资料,定期随访不同时期的复发和转移情况,评价分析手术结合放疗的预后效果。结果 18例患者中,腮腺14例,小唾液腺4例(其中腭部3例,颊部1例)。腮腺患者经浅叶/全叶切除及术后放疗,小涎腺患者经扩大切除及术后放疗。放疗总剂量为46~60Gy。随访时间6~161个月,平均(52.3±36.1)个月。2例分别于术后8a和术后13a失访,最后一次随访结果无局灶及远处复发或转移。16例患者经综合治疗后均无局灶远处复发或转移。18例患者头颈部放疗后照射区无继发恶性肿瘤。结论手术联合术后放疗治疗涎腺腺泡细胞癌效果好。
Objective To investigate the clinical effect of surgery combined with postoperative radiotherapy on salivary acinar cell carcinoma. Methods The clinical data of 18 salivary acinar cell carcinoma patients undergoing surgery and postoperative radiotherapy admitted to the Maxillofacial Oncology Department of the First Affiliated Hospital of Xinjiang Medical University from 2003 to 2016 were retrospectively analyzed. The recurrence and metastasis , Evaluate the prognosis of surgery combined with radiotherapy. Results Of the 18 patients, 14 were parotid and 4 were small salivary glands (3 in the palate and 1 in the cheek). Parotid gland patients after the light / whole leaf resection and postoperative radiotherapy, patients with small salivary glands after resection and radiotherapy. The total dose of radiation is 46 ~ 60Gy. The follow-up time ranged from 6 to 161 months, with an average of (52.3 ± 36.1) months. Two patients were lost to follow-up at 8a and postoperative 13a, respectively. There was no focal or distant recurrence or metastasis in the last follow-up. All 16 patients had no distant recurrence or metastasis after comprehensive treatment. Eighteen patients had no secondary malignant tumor in the irradiated area after head and neck radiotherapy. Conclusion Surgery combined with postoperative radiotherapy for salivary acinar cell carcinoma is effective.