桂附地黄口服液系桂附地黄丸的剂型改造。桂附地黄丸收载于《中国药典》1985年版一部,具有温补肾阳的功效。临床主要用于肾阳不足,腰膝酸冷,肢体浮肿,小便不利或反多,痰饮喘咳,消渴病症。本实验对口服液和丸剂进行了药理研究。结果表明,桂附地黄口服液和丸剂在500mg/kg/日(相当生药量)用量时能明显对抗醋酸可的松所致的大鼠体重、脾脏、肾上腺重量及血浆皮质酮含量降低;两剂型用量5g/kg/日(生药量)时能明显增强小鼠 Guifu Dihuang Oral Liquid Modified Guifudihuang Pills. Gui Fu Di Huang Wan contained in the “Chinese Pharmacopoeia” 1985 edition, with warming kidney yang effect. The main clinical application of kidney yang deficiency, cold waist and knees, limb edema, urine unfavorable or anti-duo, phlegm cough, diabetes disease. This experiment carried out pharmacological studies on oral liquids and pills. The results showed that Guifu Dihuang Oral Liquid and Pills significantly reduced the body weight, spleen, adrenal gland weight, and plasma corticosterone content of cortisone acetate-induced rats at a dose of 500 mg/kg/day (a considerable amount of crude drug); When the dosage is 5g/kg/day (crude drug amount), mice can be significantly enhanced