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乙型肝炎e抗原(HBeAg)、乙型肝炎病毒脱氧核糖核酸(HBV-DNA)和DNA多聚酶为乙型肝炎病毒(HBV)有活动性复制的血清学标记。慢性乙型肝炎患者的血清HBeAg消失和e抗体(抗-HBe)出现,常伴有血清HBV-DNA和DNA多聚酶消失及活动性肝病临床和生化指标好转,一般认为这类病人无HBV复制和无肝炎活动。已有不少报道,在应用化疗或免疫抑制剂后抗-HBe阳性的慢性HBsAg携带者出现肝炎再活动,但慢性HBV感染的自发再活动则未见有详细记载。作者随访25例HBeAg转阴者,有8例出现自发再活动。方法:25例慢性乙型肝炎有症状患者,均经肝活检证实。初期血清HBsAg和HBeAg阳性,以后转为阴性。转阴后门诊随访6个月以上(13～57月),对血清
Hepatitis B e antigen (HBeAg), Hepatitis B virus DNA (HBV-DNA) and DNA polymerase are hepatitis B virus (HBV) active replication serological markers. Serum HBeAg disappearance and e antibody (anti-HBe) in patients with chronic hepatitis B, often accompanied by the disappearance of serum HBV DNA and DNA polymerase and the improvement of clinical and biochemical indicators of active liver disease, is generally considered that such patients have no HBV replication and no Hepatitis activity. There have been many reports of hepatitis reactivation in anti-HBe-positive chronic HBsAg carriers after chemotherapy or immunosuppressive agents, but no spontaneous reactivation of chronic HBV infection is described in detail. The authors followed up 25 cases of HBeAg-negative, 8 cases of spontaneous reactivation. Methods: Twenty-five patients with symptomatic chronic hepatitis B were confirmed by liver biopsy. Initial serum HBsAg and HBeAg positive, later turned negative. Negative clinic visits were more than 6 months (13 to 57 months), the serum