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以人胃癌细胞株为实验对象,采用MTT显色法在体外观察了金属类抗癌药物氯化镓与人α-干扰素的协同抑制作用。结果显示:单独加入α-干扰素无明显抑制作用,而与氯化镓同时加入则有明显的抑制作用,尤其是当先用α-干扰素或氯化镓孵育72h后,再交换加药其协同抑制作用更大。提示:在应用氯化镓治疗胃癌病人时可同时合用干扰素治疗,或先用α-干扰素一段时间再用氯化镓治疗其疗效可能更好。
Using human gastric cancer cell lines as experimental subjects, the synergistic inhibitory effect of metal anticancer drugs guanidine chloride and human α-interferon was observed in vitro using MTT colorimetry. The results showed that there was no significant inhibitory effect of α-interferon alone, but it was significantly inhibited when added together with cesium chloride, especially when incubated with α-interferon or cesium chloride for 72 hours before exchange and dosing. Synergistic inhibition is greater. Tip: The use of cesium chloride in the treatment of gastric cancer patients can be combined with interferon therapy, or treatment with alpha-interferon for a period of time before the use of cesium chloride may be better.