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已证明三组分无细胞百日咳疫苗 DTP( DTPa)〔 GSKBio( 3)〕和五组分 DTPa〔 AV-P( 5)〕在临床试验中具有相同的效力 ,但应用小鼠鼻内攻击模型研究免疫原组分作用发现 ,三组分 GSKBio联合抗原的保护性明显低于五组分 AV- P联合抗原。为此 ,作者研究了不同铝盐对百日咳杆菌组分的
The three-component acellular pertussis vaccine DTP (DTPa) 〔GSKBio (3)〕 and the five-component DTPa [AV-P (5)〕 have been shown to have the same efficacy in clinical trials but have been tested in a mouse intranasal challenge model Immunogen components found that three-component GSKBio antigen protection was significantly lower than the five component AV-P combination antigen. To this end, the authors studied the effects of different aluminum salts on B. pertussis components