论文部分内容阅读
目的调查新生儿脐带血25-羟基Vit D[25(OH)D]水平与出生体重的关系,为低出生体重新生儿Vit D营养的合理补充提供依据。方法收集2012年2月-2014年12月在广西壮族自治区柳州市妇幼保健院出生的476例低出生体重儿(<2 500 g)和570例正常出生体重儿(≥2 500 g)脐带血25(OH)D水平与出生体重,按出生体重分为4组:A组59例(≥1 000 g且<1 500 g)、B组417例(≥1 500 g且<2 500 g)、C组528例(≥2 500 g且<4 000 g)、D组42例(≥4 000 g)。结果 1新生儿脐带血25-(OH)D平均水平为(45.20±16.93)nmol/L。有67.59%(707/1 046)的新生儿25(OH)D缺乏或不足,其中严重缺乏占0.29%(3/1 046)、缺乏占32.79%(343/1 046)、不足占34.51%(361/1 046)。充足者仅占32.41%(339/1 046);2低出生体重儿脐带血25-(OH)D水平明显低于正常出生体重儿,差异有统计学意义(t=13.812,P=0.000)。3A组与B组比较、C组与D组比较,差异均无统计学意义(t=2.287,P=0.023;t=0.925,P=0.302);A组与C组及D组比较、B组与C组及D组比较,差异均有统计学意义(F=27.006,P=0.000;F=81.512,P=0.000)。结论新生儿普遍存在Vit D缺乏或不足的现象,应加强新生儿特别是低出生体重儿维素Vit D的补充。
Objective To investigate the relationship between neonatal umbilical cord blood 25-hydroxy Vit D [25 (OH) D] and birth weight, and to provide a basis for rational supplementation of Vit D nutrition in low birth-weight infants. Methods A total of 476 cases of low birth weight infants (<2 500 g) and 570 cases of normal birth weight (≥2 500 g) born in Liuzhou Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region from February 2012 to December 2014 were collected. (OH) D level and birth weight were divided into 4 groups according to birth weight: 59 cases (≥1 000 g and <1 500 g) in group A, 417 cases (≥1 500 g and <2 500 g) in group B, Group 528 (≥2 500 g and <4 000 g), Group D 42 (≥ 4000 g). Results 1 The mean neonatal umbilical cord blood 25- (OH) D level was (45.20 ± 16.93) nmol / L. There were 67.59% (707/1 046) of newborns with 25 (OH) D deficiency or deficiency, with a serious lack of 0.29% (3/1 046), a lack of 32.79% (343/1 046) and a deficiency of 34.51% ( 361/1 046). Only 32.41% (339/1 046) were sufficient. 2 The level of 25- (OH) D in cord blood of children with low birth weight was significantly lower than that of normal birth weight (t = 13.812, P = 0.000). There was no significant difference between group 3A and group B (P <0.05). There was no significant difference between group C and group D (t = 2.287, P = 0.023; Compared with group C and group D, the differences were statistically significant (F = 27.006, P = 0.000; F = 81.512, P = 0.000). Conclusions There is a common deficiency or deficiency of Vit D in newborns. The supplement of vitamin D in newborns, especially those with low birth weight, should be strengthened.