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我科自1996年～1997年应用纳洛酮治疗新生儿缺氧缺血性脑病50例,疗效尚满意,现报告如下。 1 临床资料 1.1 诊断标准:按金汉珍主编的《实用新生儿学》中制定的新生儿缺氧缺血性脑病的诊断标准。 1.2 病例选择:将凡符合上述诊断标准的90例新生儿缺氧缺血性脑病患儿随机分为治疗组50例,对照组40例。治疗组男37例,女13例,对照组男25例,女15例。两组均有宫内缺氧或产时窒息史,生后24小时内入院。 1.3 治疗方法:全部病例入院后均给予吸氧,激素,控制脑水肿等综合治疗,而治疗组入院后在上述治疗基础上加用静注纳洛酮0.05mg/kg/次,于30分钟后重复1次,然后再以0.4mg+10％ GS 100mL静脉点滴,以每分钟2μg的速度滴入,3天为1疗程。 1.4 疗效判断标准 1.4.1 显效:2小时内呼吸困难消失,节律规整,12
Our department from 1996 to 1997 naloxone treatment of hypoxic-ischemic encephalopathy in 50 cases, the effect is still satisfactory, are as follows. 1 clinical data 1.1 diagnostic criteria: Jin Hanzhen editor of “Practical Neonatology” in the diagnostic criteria for neonatal hypoxic-ischemic encephalopathy. 1.2 Case Selection: 90 cases of neonates with hypoxic-ischemic encephalopathy in line with the above diagnostic criteria were randomly divided into treatment group 50 cases, control group 40 cases. Treatment group, 37 males and 13 females, control group, 25 males and 15 females. Both groups had intrauterine hypoxia or asphyxia during birth, admission within 24 hours after admission. 1.3 Treatment: All patients admitted to hospital were given oxygen, hormones, cerebral edema and other comprehensive treatment, and the treatment group after admission based on the above treatment with intravenous injection of naloxone 0.05mg / kg / time, after 30 minutes Repeat 1, and then to 0.4mg + 10% GS 100mL intravenous infusion at a rate of 2μg per minute, 3 days for a course of treatment. 1.4 Therapeutic criteria 1.4.1 Markedly: 2 hours of dyspnea disappeared, rhythm and regularity, 12