论文部分内容阅读
目的:评价三种检测隐性铁缺乏症的临床应用价值。方法:用放射免疫检测血清铁蛋白(SF)、生物化学法测定血清铁(SI)和铁粒染色(取富含骨髓小粒标本)检测铁贮含量并比较其结果。结果:SF有9.5%小于本院正常值(12～245ng/L),SI有14%小于本院正常值(10.7～26.9μmol/L),铁粒染色细胞外铁(-)36例,(±)6例,铁幼粒细胞0～10%34例,11～20%8例。结论:SF、SI、铁粒染色三种方法均能了解患者体内铁贮含量,但对隐性铁缺乏症(LID)诊断的灵敏度、特异性、检测率有差别。SF、SI具有取样方便,可以对铁贮量进行定量的优点,但检出率受多种因素的影响。铁粒染色检出阳性率高、特异性强,较少受炎症、恶性疾病及仪器、试剂等多种因素的影响,在隐性铁缺乏症(LID)诊断上可视为最可靠最敏感的指标。
Objective: To evaluate the clinical value of three tests for detection of recessive iron deficiency. Methods: Serum ferritin (SF) was detected by radioimmunoassay. Serum iron (SI) and iron granule staining (using bone marrow-rich granule samples) were determined by biochemical methods and the results were compared. Results: SF was 9.5% less than normal in our hospital (12 ~ 245ng / L), SI was 14% less than normal in our hospital (10.7 ~ 26.9μmol / L) ±) in 6 cases, 0 ~ 10% in 20 cases of leukemia cells, 11 ~ 20% in 8 cases. Conclusion: SF, SI and iron granule staining all can know the content of iron in patients’ body, but the sensitivity, specificity and detection rate of the diagnosis of latent iron deficiency (LID) are different. SF, SI has the advantage of sampling convenience and quantification of iron storage, but the detection rate is affected by many factors. Iron granulometry showed high positive rate, strong specificity and less affected by many factors, such as inflammation, malignant diseases, instruments and reagents. It can be regarded as the most reliable and sensitive method in the diagnosis of latent iron deficiency (LID) index.