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抗生素广泛使用之后,细菌普遍产生耐药,β-内酰胺酶抑制剂棒酸的发现为其它抗生素钝化酶抑制剂的筛选开拓了视野。氨基糖苷类抗生素磷酸化酶(APH)是该类抗生素钝化的重要原因。本文报道建立APH酶抑制剂的筛选方法,并以烬灰链霉菌(Stre-ptomyces cinerogriseus)80-506 筛到 APH-3＇和APH3″抑制剂80-506。 80-506为大分子的多肽,可用蛋白质分
After widespread use of antibiotics, the bacteria commonly develop resistance, and the discovery of clavulanic acid, a β-lactamase inhibitor, opens the way for the screening of other antibiotic-inactivating enzyme inhibitors. Aminoglycoside antibiotics phosphorylase (APH) is an important reason for the passivation of antibiotics. This article reports the establishment of a screening method for APH enzyme inhibitors and Screening of APH-3 ’and APH3 "inhibitors 80-506 with Streptomyces cineogriseus 80-506.80-506 is a macromolecular polypeptide, Available protein points